首页> 外文OA文献 >Immunogenicity of a Heptavalent Conjugate Pneumococcal Vaccine Administered Concurrently with a Combination Diphtheria, Tetanus, Five-Component Acellular Pertussis, Inactivated Polio, and Haemophilus influenzae Type b Vaccine and a Meningococcal Group C Conjugate Vaccine at 2, 3, and 4 Months of Age ▿
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Immunogenicity of a Heptavalent Conjugate Pneumococcal Vaccine Administered Concurrently with a Combination Diphtheria, Tetanus, Five-Component Acellular Pertussis, Inactivated Polio, and Haemophilus influenzae Type b Vaccine and a Meningococcal Group C Conjugate Vaccine at 2, 3, and 4 Months of Age ▿

机译:结合使用白喉,破伤风,五成分无细胞百日咳,灭活脊髓灰质炎和乙型流感嗜血杆菌的七价结合型肺炎球菌疫苗的免疫原性,分别在2、3和4个月龄时接种C型脑膜炎球菌

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摘要

The immunogenicities of conjugate pneumococcal vaccines have been demonstrated when they are administered at 2, 3, and 4 months of age. There is a paucity of data on the immunogenicity of this vaccine when it is administered concurrently with other vaccines in the primary immunization schedule of the United Kingdom. We immunized 55 term infants at 2, 3, and 4 months of age with the seven-valent pneumococcal conjugate vaccine (PCV7), the meningococcal group C conjugate (MCC) vaccine, and the diphtheria, tetanus, five-component acellular pertussis, inactivated polio, and Haemophilus influenzae type b (DTaP5/IPV/Hib-TT) vaccine. The immune responses to the H. influenzae type b (Hib), MCC, and tetanus vaccines were measured at 2, 5, and 12 months of age; and the immune responses to PCV7 were measured at 2 and 5 months and then either at 12 months or following a 4th dose of PCV7. There were increases in the geometric mean concentrations (GMCs) of all antigens postimmunization. Greater than or equal to 90% of the infants achieved putatively protective levels postimmunization for all vaccine antigens except pneumococcal serotype 6B and Hib. The GMCs of the PCV7 serotypes increased following a 4th dose, although one infant had not reached putative levels of protection against serotype 6B. In conclusion, when infants were vaccinated according to the schedule described above, they had lower postprimary immunization responses to Hib, meningococcus group C capsular polysaccharide, and pneumococcal serotype 6B than the responses demonstrated by use of the other schedules. Despite this finding, there was a good response following a 4th dose of PCV7.
机译:当在2、3和4个月大时施用结合物肺炎球菌疫苗时,已经证明了其免疫原性。在联合王国的初次免疫日程中,与其他疫苗同时施用时,该疫苗的免疫原性数据很少。我们使用灭活的七价肺炎球菌结合疫苗(PCV7),脑膜炎球菌C组结合物(MCC)疫苗和白喉,破伤风,五组分脱细胞百日咳灭活了55个足月婴儿,分别于2、3和4个月进行了免疫脊髓灰质炎和乙型流感嗜血杆菌(DTaP5 / IPV / Hib-TT)疫苗。在2、5和12个月大时测量了对b型流感嗜血杆菌(Hib),MCC和破伤风疫苗的免疫反应;在第2和5个月测量其对PCV7的免疫应答,然后在第12个月或第4剂PCV7后测量。免疫后所有抗原的几何平均浓度(GMC)增加。大于或等于90%的婴儿对除肺炎球菌血清型6B和Hib以外的所有疫苗抗原均达到了免疫后公认的保护水平。第4剂后PCV7血清型的GMC升高,尽管一个婴儿尚未达到针对6B血清型的公认保护水平。总之,按照上述时间表对婴儿进行疫苗接种时,他们对Hib,脑膜炎球菌C组荚膜多糖和肺炎球菌血清型6B的初次免疫应答比使用其他时间表证明的应答要低。尽管发现了这一发现,但在第四剂PCV7后仍然有良好的反应。

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